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. Author manuscript; available in PMC: 2013 May 21.
Published in final edited form as: Nat Struct Mol Biol. 2011 Nov 4;18(11):1181–1182. doi: 10.1038/nsmb.2170

Figure 2.

Figure 2

Model of TNRC6 interaction with the CCR4–NOT and PAN2–PAN3 deadenylase complexes in humans. Protein sizes are drawn to scale. GW repeats in the N and C termini of human TNRC6 proteins are indicated and bind CNOT1. The TNRC6 N-terminal region also interacts with Ago proteins. The PAM2 domain of TNRC6 associates with PAN3 and PABP1. Recruitment of CCR4–NOT by GW repeats and PAN2–PAN3 by the PAM2 motif or flanking GW repeats causes deadenylation of target mRNAs and translation inhibition. In fly, TNRC6 corresponds to Gawky, and CNOT proteins are termed NOT proteins except for CNOT6, CNOT7 and CNOT9, which are named Twin, Pop2 and CAF40, respectively. Human CNOT6L is a paralog of CNOT6, and CNOT8 is a paralog of CNOT7, and each family is represented as single-copy genes in fly.