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. Author manuscript; available in PMC: 2013 May 21.
Published in final edited form as: Biochem Pharmacol. 2004 Mar 1;67(5):805–814. doi: 10.1016/j.bcp.2004.01.002

Fig. 1.

Fig. 1

Differing levels of Hedgehog stimulation specify distinct cell fates. Hh diffusing into a field of cells specifies differing cell fates in cells near and far from the Hh source. In the Drosophila wing imaginal disc, the level of Hh stimulation controls target gene activation by regulating the relative amounts of Ci transcriptional repressors (Ci75) and activators (Ciact and Ci*). Ci transcription factors then control expression of specific subsets of genes to establish cell fate for development of specific adult structures. iro: iroquois; col: collier; kn: knot; ptc: patched; en: engrailed.