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Model depicting how the Hh gradient regulates Hedgehog Signaling Complex activator and repressor functions. In the cell receiving no Hh (left cell), HSC-R is producing Ci75 and HSC-A is inactive. In the middle cell, HSC-A is producing Ciact. However, Ciact may be acting in the presence of a lower amount of Ci75. In the cell receiving the greatest amount of Hh (right cell), HSC-A is maximally activated by Smo multimerization, and HSC-R is completely off.
