Table 2.
Comparison of prognostic indicators for response to preoperative chemotherapy in patients with colorectal liver metastases
| Indicators | n | median survival (months) |
Overall Survival |
P | ||
|---|---|---|---|---|---|---|
| 1-year | 3-year | 5-year | ||||
| RECIST (MD Anderson unpublished data) | ||||||
| PR | 69 | 88 months | 94% | 78% | 62% | 0.063 |
| SD or PD | 119 | 50 months | 95% | 62% | 45% | |
|
Pathologic response (Blazer et al, J Clin Oncol 2008[15]) |
||||||
| Complete response | 25 | NA | 100% | 100% | 75% | 0.037 0.028 |
| Major response | 97 | 76 months | 95% | 69% | 56% | |
| Minor response | 149 | 42 months | 91% | 58% | 33% | |
|
Morphologic response (Shindoh et al, J Clin Oncol, in press[18]) |
||||||
| Optimal response | 63 | 114 months | 98% | 82% | 74% | 0.0009 |
| Suboptimal response | 146 | 49 months | 93% | 60% | 45% | |
Abbreviations. PR, partial response; SD, stable disease; PD, progressive disease; NA, not available