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. Author manuscript; available in PMC: 2013 May 21.
Published in final edited form as: Semin Immunopathol. 2010 Jul 9;32(3):239–255. doi: 10.1007/s00281-010-0214-z

Figure 1. Germinal center orientation and zones.

Figure 1

(A) Cartoon of GC architecture within a B cell follicle; DZ (purple), LZ (red), OZ (yellow), FM (green). (B) Murine spleen obtained 12 days after ip immunization. An Ig H chain gene knockin strain that encodes for an anti-hapten specificity in ~5% of B cells was immunized with NP-CGG prepared in alum. Staining for anti-IgD-AL488 (green) and anti-CD35-bi/SA-AL568 (red). (C) Lymph node section obtained 9 days after footpad immunization in complete Freunds adjuvant stained for anti-IgD-AL488 (green), PNA-bi/SA-AL568 (red) and anti-CD4-AL647 (blue).