Table 4.
Biomarkers | Peak intensity (mean ± sd, n = 6) | ||||
---|---|---|---|---|---|
Control | Con. + CDDP | Sham | Model | Mod. + CDDP | |
Glycine | 5.86 ± 0.6b,c | 5.51 ± 0.96b | 4.85 ± 0.94a | 4.41 ± 1.65a | 5.94 ± 1.8b,c |
Urea | 190.9 ± 112.08b | 201.44 ± 108.76b | 201.59 ± 55.12b | 282.23 ± 72.75a,c | 211.97 ± 48.32b |
L-alanine | 444.97 ± 64.71b | 432.48 ± 74.21b | 450.96 ± 56.85b | 586.25 ± 64.89a,c | 443.53 ± 98.11b |
L-isoleucine | 260.88 ± 34.02b,c | 254.42 ± 39.69b | 211.84 ± 34.61a,b | 192.58 ± 33.25ac | 205.51 ± 54.06a |
Cadaverine | 22.75 ± 11.3b | 23.12 ± 4.15b | 21.68 ± 11.31b | 45.53 ± 11.1a,c | 36.9 ± 14.92b |
Succinic acid | 3.12 ± 2.16b | 3.13 ± 0.94b | 3.13 ± 1.63b | 2.40 ± 1.01a | 3.01 ± 2.07b |
2-Butenedioic acid | 4.74 ± 1.61b | 4.61 ± 3.24b | 4.23 ± 3.98b | 1.24 ± 3.92a,c | 3.37 ± 3.98a,b |
L-threonine | 209.33 ± 25.38b,c | 208.3 ± 27.54b | 181.25 ± 22.81a,b | 164.77 ± 35.78a,c | 189.33 ± 44.05b |
Aminomalonic acid | 46.73 ± 29.21b | 46.21 ± 18.02b | 43.69 ± 44.56b | 36.41 ± 28.42a,c | 39.85 ± 25.14a |
L-aspartic acid | 100.32 ± 11.51b | 97.98 ± 13.89b | 102.57 ± 7b | 112.83 ± 13.89a,c | 104.12 ± 21.12b |
L-proline | 280.57 ± 22.74b,c | 289.33 ± 56.22b | 218.72 ± 31.35a,b | 95.1 ± 15.54a,c | 248.84 ± 64.37b |
Creatinine | 6.39 ± 1.59b,c | 6.27 ± 3.44b | 7.25 ± 3.23a,b | 8.7 ± 3.73ac | 7.71 ± 3.24a,b |
L-phenylalanine | 110.09 ± 10.46b,c | 106.57 ± 14.11b | 126.76 ± 8.24a,b | 177.46 ± 12.68a,c | 148.95 ± 24.79a,b |
Citric acid | 6.95 ± 5.52b | 6.83 ± 4.4b | 6.33 ± 4.45b | 5.75 ± 2.64a,c | 6.06 ± 3.71a,b |
D-xylose | 7.01 ± 1.96b,c | 7.08 ± 1.06b | 8.13 ± 1.07a,b | 9.76 ± 1.77a,c | 8.07 ± 1.15b |
D-glucose | 2912.13 ± 190.45b | 2993.74 ± 210.95b | 3239.06 ± 255.96b | 5506.4 ± 255.01a,c | 3012.34 ± 209.33b |
Lactic acid | 210.17 ± 15.22b | 211.91 ± 22.87b | 238.35 ± 16.13b | 381.36 ± 24.33a,c | 258.68 ± 16.45b |
L-tyrosine | 44.57 ± 5.36b,c | 43.47 ± 7.74b | 56.62 ± 5.38a,b | 67.94 ± 9.93a,c | 62.72 ± 9.05a |
Propanoic acid | 21.98 ± 6.65b,c | 22.5 ± 10.64b | 11.98 ± 6.28a | 10.89 ± 9.27a | 14.96 ± 10.47a,b |
L-tryptophan | 421.7 ± 67.69b | 417.94 ± 69.49b | 434.8 ± 82.32b | 478.28 ± 118.65a,c | 451.78 ± 101.75a,b |
Compared with the control group, a P < 0.05; compared with the model group, b P < 0.05; compared with the sham group, c P < 0.05.