Table 3.
IC50 values (μg/mL) of ROS inhibitory and chemotaxis activities of Phyllanthus sp. and their chemical markers on phagocytes (Mean ± SEM, n = 3). IC50 values in μM are in parentheses.
| Sample | Chemotaxis | Chemiluminescence | |
|---|---|---|---|
| Whole blood | PMNs | ||
| Phyllanthus amarus (Ind) | 5.1 ± 0.4 | 5.2 ± 1.1 | 1.9 ± 0.1 |
| Phyllanthus urinaria (Ind) | 5.4 ± 0.7 | 11.9 ± 0.9 | 1.9 ± 0.1 |
| Phyllanthus amarus (Mal) | 1.1 ± 0.1 | 1.1 ± 0.9 | 0.7 ± 0.2 |
| Phyllanthus urinaria (Mal) | 1.4 ± 0.2 | 1.6 ± 0.5 | 0.7 ± 0.3 |
| Phyllanthin | 3.2 ± 0.1 | 3.7 ± 2.8 | 3.2 ± 0.8 |
| (7.6 ± 0.1 μM) | (8.8 ± 1.0 μM) | (7.6 ± 0.4 μM) | |
| Hypophyllanthin | 4.4 ± 0.2 | 3.6 ± 1.4 | 6.1 ± 2.3 |
| (10.2 ± 0.4 μM) | (8.4 ± 1.3 μM) | (14.2 ± 1.7 μM) | |
| Ibuprofen | 1.4 ± 0.1 | ||
| (6.8 ± 0.1 μM) | |||
| Aspirin | 2.2 ± 0.8 | 1.9 ± 0.2 | |
| (12.2 ± 1.1 μM) | (10.5 ± 2.1 μM) | ||