Fig. 5. Down-regulation of dendritic cell maturation and immune system in the old rat treated with Korean red ginseng (KRG, young vs. old rat+KRG groups). Ingenuity Pathway Analysis of genes between the old rat+KRG and the young rat showed 2 networks. (A) The network with a score of 28 has 11 focus molecules, which had functions in developmental disorders, genetic disorders, and the reproductive system. Expression of four genes was increased (Rpl10a, Sv2b, Serpinb6a, and DDX6), and expression of 8 genes was decreased (Cldn5, Hbb, Tmem97, HLADRB1, Degs1, HLAC, Insl3, and HLA-ABC) in the old rat+KRG group. The numbers under the gene name show change of gene expression in log2 basis. Red color indicates increase of gene expression whereas green color decrease of gene expression. (B) The network with a score of 22 has 9 focus molecules, whose functions are involved in cell morphology, lipid metabolism, and molecular transport. Expression of three genes was increased (Syf2, PLEKHA1, and ARHGAP32), and expression of 8 genes was decreased (Col1a2, Hsd11b1, Insl3, Orai1, PROCA1, collagen, PLA2, and Svs5) in the old rat+KRG group.