Fig. 7. Up-regulation of C21-steroid hormone metabolism by Korean red ginseng (KRG) treatment (old rat vs. old rat+KRG groups). Ingenuity Pathway Analysis of genes between the old rat+KRG group and the old rat showed 2 networks. (A) The network with a score of 28 has 10 focus molecules, which includes functions in small molecule biochemistry, developmental disorders, and lipid metabolism. Expression of four genes was increased (Cyp11a1, Rps9, Sv2b, and Egln2), and Expression of 7 genes was decreased (Vdac3, Svs5, Degs1, Insl3, Tmem97, HLA-DRB1, and HLA-DR) in the old rat+KRG group. (B) The network with a score of 2 has 1 focus molecule, which has functions in cellular assembly and organization, cellular function and maintenance, and dermatological diseases. Gene expression was increased (FUNDC2) in the old rat+KRG group.