Table 1.
Inhibitory activity (IC50) of 10 ginsenosides isolated from air-dried leaves of PG on TNF-α induced NF-κB activation in HepG2 cells
| Compound | IC50 (μM)1) |
|---|---|
|
| |
| Ginsenoside F1 | 22.36±2.20 |
| Ginsenoside Rb1 | 27.45±3.69 |
| Ginsenoside Rb2 | 67.18±3.57 |
| Ginsenoside Rc | ND |
| Ginsenoside Rd | 12.05±0.82 |
| Ginsenoside Re | ND |
| Ginsenoside Rg1 | 28.14±0.28 |
| Ginsenoside Ki | 21.45±3.69 |
| Ginsenoside Km | 8.84±0.99 |
| Vinaginsenoside R4 | 47.21±3.69 |
| PDTC 2) | 3.35±0.61 |
p˂0.05, compared to normal or control group.
PG, Panax ginseng; TNF, tumor necrosis factor; NF, nuclear factor; ND, not detected; PDTC, pyrrolidine dithiocarbamate.
1)Results are the means±SEM of three independent experiments performed in triplicate.
2)Positive control.