Table 1.
Changes on the histomorphometrical analysis of liver
| Groups | Percentages of degenerative regions (%/mm2 of hepatic parenchyma) | Numbers of degenerative hepatocytes (cells/1000 hepatocytes) | Collagen deposited percentages (%/mm2 of hepatic parenchyma) |
|---|---|---|---|
|
| |||
| Lateral lobes | |||
| Vehicle | 0.20±0.12 | 5.80±2.05 | 0.34±0.11 |
| CCl4 | 66.90±15.10** | 159.20±58.41** | 11.86±3.48** |
| CCl4 + RGE 30 mg/kg | 42.94±14.70**,## | 103.20±29.45** | 4.72±1.20**,## |
| CCl4 + RGE 100 mg/kg | 30.64±16.05**,## | 89.60±20.90**,## | 3.82±0.94**,## |
| CCl4 + RGE 300 mg/kg | 28.40±10.83**,## | 91.20±11.80**,## | 3.34±1.32**,## |
| Median lobes | |||
| Vehicle | 0.84±1.00 | 13.60±10.33 | 0.32±0.19 |
| CCl4 | 57.48±12.05** | 168.80±30.78** | 10.04±0.97** |
| CCl4 + RGE 30 mg/kg | 41.04±8.52**,# | 112.80±33.75**,## | 6.92±1.27**,## |
| CCl4 + RGE 100 mg/kg | 34.70±12.11**,# | 94.40±30.54**,## | 5.16±1.27**,## |
| CCl4 + RGE 300 mg/kg | 35.42±9.86**,# | 102.40±23.43**,## | 5.12±2.55**,## |
All values were expressed as mean±SD of five mice (significant as compared to vehicle-treated group, **p<0.01; significant as compared to CCl4-treated group ##p<0.01, #p<0.05).
CCl4, carbon tetrachloride; RGE, red ginseng extract.