Fig. 4. Inhibition of melastatin type transient receptor potential 7 (TRPM7)-like currents by ginsenoside Rd (G-Rd) in AGS and MCF-7 cells. (A) Effect of G-Rd on TRPM7-like currents in AGS cells. I–V curves (a) and a summary bar graph (b) in the absence (■) or presence (●) of G-Rd. (c) Concentration-dependent inhibition of TRPM7-like current by G-Rd in AGS cells. The estimated median inhibitory concentration value was 170 μM. The saturation concentration might be 500 μM. (B) Effect of G-Rd on TRPM7-like currents in MCF-7 cells. I–V curves (a) and a summary bar graph (b) in the absence (■) or presence (●) of G-Rd. (c) Concentration-dependent inhibition of TRPM7-like current by G-Rd in MCF-7 cells. The estimated median inhibitory concentration value was 178 μM. The saturation concentration might be 500 μM. **p<0.01.
