Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Nov 27;1(12):866–873. doi: 10.5966/sctm.2012-0045

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

©AlphaMed Press 1066-5099/2012/$20.00/0

PMC Copyright notice

Figure 3. — In vivo magnetic resonance (MR) imaging of tumor tropism of human neural stem cells after intranasal delivery. (A): Axial section of a susceptibility-weighted MR image prior to intranasal delivery of superparamagnetic iron oxide particle (SPIO)-labeled HB1.F3 cells displaying an NCE-G55T2 human glioblastoma xenograft in the right forebrain (insets: magnified tumor area). (B): Three days after intranasal delivery hypointensive signals (arrow) in the tumoral area indicated a tumor-targeted migration of SPIO-labeled HB1.F3 cell clusters. (C): Five days after intranasal delivery the hypointensive signals (SPIO-labeled HB1.F3 cell clusters) had spread over the tumoral area. (D): Prussian blue staining confirmed MR imaging results demonstrating that SPIO-labeled HB1.F3 cells (blue, arrowhead) accumulated at the tumor border (arrows). Scale bar = 50 μm. (E): Prussian blue staining of SPIO-labeled HB1.F3 cells (blue, arrowhead) within the glioma mass. Scale bar = 20 μm. (F): Tumor tropism of human neural stem cells after intranasal administration was confirmed by intratumoral enrichment of intranasally delivered DiI-labeled HB1.F3 cells (arrowhead). Scale bar = 50 μm.