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Hematopoietic stem and progenitor cells (HSPCs) engrafted on NOD.Cg-prkdcscid IL2rgtm1Wjl/SzJ mouse. (A): Example of human cell engraftment in the bone marrow of a mouse 8.5 weeks after transplantation with HSPCs. (B): Analysis of spleen of same mouse. All subsequent analysis of lineage distribution is among the CD45+ population. Antibodies identify specific human cell lineages, as described in Materials and Methods. Abbreviation: SS, side scatter.
