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. 2012 Jul 6;1(7):548–556. doi: 10.5966/sctm.2011-0063

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©AlphaMed Press 1066-5099/2012/$20.00/0

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Figure 4. — SB203580 retained the motor function of Atm^−/− mice. (A): Motor coordination of 2-month-old Atm^+/+ and Atm^−/− mice was analyzed by measuring the time before falling off the rotating beam at 25 rpm with three trials. Values represent means ± SD of time on the rotating rod (Atm^+/+, n = 4; Atm^−/−, n = 4; three independent tests; ***, p < .001). The body weights of 2-month-old Atm^+/+ and Atm^−/− mice were also measured. Values represent means ± SD of body weights (Atm^+/+, n = 4; Atm^−/−, n = 4; three independent tests; *, p < .05). (B): After treatment with antioxidant NAC and MSL, motor coordination of adult (postnatal day 90 [P90]) Atm^+/+, Atm^−/−, Atm^−/−+NAC, and Atm^−/−+MSL mice were analyzed. Values represent means ± SD of time on the rotating beam (n = 6 per group; three independent tests; **, p < .01, *, p < .05). (C): After treatment, the motor coordination of adult (P90) Atm^+/+, Atm^−/−, and Atm^−/−+SB203580 (SB) mice was assessed by measuring the time before falling off the rotating beam at 25 rpm with three trials. Values represent means ± SD of time on the rotating beam (Atm^+/+, n = 10; Atm^−/−, n = 9; Atm^−/−+SB, n = 10; three independent tests; ***, p < .001, **, p < .01). (D): After treatment, the body weights of adult (P90) Atm^+/+, Atm^−/−, and Atm^−/−+SB mice were measured. Values represent means ± SD of body weights (Atm^+/+, n = 10; Atm^−/−, n = 9; Atm^−/−+SB, n = 10; three independent tests; ***, p < .001, *, p < .05). Abbreviations: MSL, monosodium luminol; NAC, N-acetyl-l-cysteine; UT, untreated.