Figure 5.

PluriTest output. The background encodes an empirical density map indicating pluripotency and novelty as indicated by the color bar. In the red area, corresponding to fully reprogrammed cells, cluster the iPSC SSEA4-high (yellow circles), hESCs (red circles), and iPSC data provided by Müller et al. [17] (green circles). In the middle area, corresponding to partially reprogrammed cells, are the iPSC SSEA4-low (dark blue circles). Fibroblasts (light blue circles) and astrocytes (purple circle) cluster together at the area corresponding to somatic cells. Circles surrounded by a black line are the results of cell lines provided by Müller et al. [17]. Abbreviations: ESC, embryonic stem cell; iPSC, induced pluripotent stem cell; PSC, pluripotent stem cell; SSEA4, stage-specific embryonic antigen-4.