Figure 6.

Diagram representing different outcomes of reprogramming progression for the generation of iPSC lines. The success of generating iPSCs depends on the appropriate progression through the reprogramming path from a somatic cell to the fully reprogrammed iPSC. Some cells will deviate from this path, reaching only a partially reprogrammed state. However, these cells may convert subsequently to the fully reprogrammed state. Our results demonstrated the converse, that fully reprogrammed iPSCs can regress to the partially reprogrammed state, even after previously fulfilling stringent definitions of pluripotency, including teratoma formation. Abbreviation: iPSC, induced pluripotent stem cell.