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. 2013 Feb 13;2(3):233–242. doi: 10.5966/sctm.2012-0096

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Figure 3. — Pharmacodynamic assessment of PF-03084014 alone and in combination with docetaxel in breast xenograft models (n = 5 mice per group). The values are the means ± SEM. (A–C): The data were generated using HCC1599 tumors. (A, C): Western blot analysis of biomarkers on day 2 (A) and day 19 (C) after dosing commencement. (B): Notch target gene modulations on day 19 after treatment. (D): Serum levels of IL-6 or IL-8 on day 15 after dosing commencement in multiple models. (E): Changes in the endothelial mesenchymal transition markers and ABC transporters were observed in MDA-MB-231Luc tumor on day 19. Abbreviations: Doce, docetaxel; E-Cad, E-cadherin; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; PF, PF-03084014; Veh, vehicle.