Table A2.

The association between grand-paternal and grand- maternal age and risk of schizophrenia: Male grandchild

Grandparent age (years)	Count of cases	%	Count of controls	%	Adjusted Odds Ratio	Lower 95% CI	Upper 95% CI
Maternal GF age
<20	23	1.48	121	1.23	1.20	0.74	1.94
20–24	205	13.23	1300	13.19	Reference
25–29	393	25.35	2727	27.66	0.92	0.76	1.12
30–34	370	23.87	2556	25.93	0.93	0.75	1.15
35–39	278	17.94	1753	17.78	1.00	0.79	1.28
40–44	163	10.52	881	8.94	1.19	0.90	1.58
45–49	72	4.65	355	3.60	1.39	0.98	1.98
50–54	27	1.74	130	1.32	1.43	0.88	2.32
≥ 55	19	1.23	35	0.36	3.64	1.97	6.74
Maternal GM age
<20	98	6.32	618	6.27	0.99	0.77	1.27
20–24	398	25.68	2588	26.25	Reference
25–29	410	26.45	2873	29.14	0.93	0.80	1.10
30–34	357	23.03	2162	21.93	1.01	0.84	1.22
35–39	211	13.61	1152	11.69	1.01	0.80	1.28
40–44	69	4.45	437	4.43	0.76	0.55	1.07
≥ 45	7	0.45	28	0.28	1.07	0.44	2.56
Paternal GF age
<20	20	1.29	85	0.86	1.46	0.87	2.44
20–24	202	13.03	1263	12.81	Reference
25–29	409	26.39	2657	26.95	0.95	0.78	1.15
30–34	420	27.10	2588	26.25	0.97	0.78	1.20
35–39	263	16.97	1763	17.88	0.88	0.69	1.13
40–44	151	9.74	969	9.83	0.92	0.69	1.22
45–49	49	3.16	370	3.75	0.77	0.52	1.13
50–54	23	1.48	118	1.20	1.11	0.66	1.87
≥ 55	13	0.84	45	0.46	1.72	0.88	3.38
Paternal GM age
<20	91	5.87	512	5.19	1.15	0.89	1.49
20–24	375	24.19	2552	25.89	Reference
25–29	463	29.87	2858	28.99	1.13	0.97	1.33
30–34	355	22.90	2211	22.43	1.14	0.95	1.38
35–39	188	12.13	1270	12.88	1.08	0.85	1.37
40–44	74	4.77	429	4.35	1.24	0.89	1.73
≥ 45	4	0.26	26	0.26	1.02	0.34	3.06

^*Adjusted for age of spouse, birth year and sex of proband

GM -= grandmother; GF = grandfather. Significant results shown in bold