FIG. 4.

Intravenous (i.v.) MgCl₂ treatment increased microvascular perfusion without increasing hemorrhage following spinal cord injury. (A) Shown are the percentages of RECA+ or LEA+ microvessels in the epicenter plus penumbra at 24 and 48 h. As shown also in a separate experiment (Fig. 2), the control phosphate-buffered saline (PBS)-treated animals displayed hypoperfusion status (LEA lower than RECA). The vasodilatory effect of MgCl₂ is still seen at 48 h, but the total number of microvessels is less than at 24 h. (B) There is no change in the area of hemorrhage with the MgCl₂ treatment at 24 h post-injury. n=5 per group. *p<0.05.