FIG. 7.

Chronic spinal cord injury (SCI) results in marked deregulation of ω-3 (A) and ω-6 (B) Polyunsaturted fatty acid (PUFA) metabolic pathways corrected by ω-3 PUFA-enriched diet. Green (decrease) and red (increase) arrows represent statistically significant alterations when compared with controls (two-way analysis of variance followed by post-hoc testing was performed. Differences were significance at p<0.05). (C) Box and whiskers legend depict metabolite relative levels relative to the median metabolite levels in each group. For each ω-3 and ω-6 PUFA metabolite, variable influence on projection (VIP) values were included for projections to latent structures discriminant analysis principal component (PC) 1 and 2. For each component, VIP scores higher than 1 are considered significant contributors to the group separations. (D) Summary of PUFA biosynthetic pathways. AA, arachidonic acid; DGLA, dihomo-γ-linolenic acid; GLA, γ-linolenic acid; DPA, docosapentaenoic acid; SDA, stearidonic acid; PG, prostaglandins; LT, leukotrienes; TX, thromboxanes; HEPE, hydroxyeicosapentaenoic acid; HETE, hydroxyeicosatetraenoic acid; HODE, hydroxyoctadecadienoic acid. Color image is available online at www.liebertpub.com/neu