Table 3.
Association of BMI-Related SNPs and Anthropometric Traits in European Ancestry Participants
| SNP | Nearest Gene | Health ABC | AGES-Reykjavik | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Midlife weight, kg | Weight, kg | BMI, kg/m2 | Midlife weight, kg | Weight, kg | BMI, kg/m2 | ||||||||||||||
| N | Allele Effect Size (β) | p | N | Allele Effect Size (β) | p | N | Allele Effect Size (β) | p | N | Allele Effect Size (β) | p | N | Allele Effect Size (β) | p | N | Allele Effect Size (β) | p | ||
| rs1558902 | FTO | 1,630 | 0.03 | .44 | 1,663 | 0.03 | .30 | 1,662 | 0.06 | .03 | 3,207 | 0.02 | .26 | 3,216 | 0.03 | .22 | 3,216 | 0.03 | .09 |
| rs2867125 | TMEM18 | 1,630 | 0.05 | .11 | 1,663 | 0.03 | .25 | 1,662 | 0.04 | .09 | 3,207 | −0.02 | .47 | 3,216 | −0.01 | .68 | 3,216 | −0.01 | .69 |
| rs571312 | MC4R | 1,630 | 0.06 | .08 | 1,663 | 0.02 | .45 | 1,662 | 0.03 | .22 | 3,207 | 0.05 | .01 | 3,216 | 0.03 | .13 | 3,216 | 0.03 | .12 |
| rs10938397 | GNPDA2 | 1,630 | 0.11 | .001 | 1,663 | 0.08 | .008 | 1,662 | 0.05 | .03 | 3,207 | −0.01 | .64 | 3,216 | −0.01 | .74 | 3,216 | −0.01 | .49 |
| rs10767664 | BDNF | 1,630 | 0.06 | .06 | 1,663 | 0.03 | .26 | 1,662 | 0.02 | .51 | 3,207 | 0.04 | .09 | 3,216 | 0.05 | .01 | 3,216 | 0.04 | .01 |
| rs2815752 | NEGR1 | 1,630 | 0.07 | .03 | 1,663 | 0.03 | .35 | 1,662 | 0.02 | .38 | 3,207 | 0.03 | .10 | 3,216 | 0.02 | .40 | 3,216 | 0.02 | .34 |
| rs7359397 | SH2B1 | 1,630 | 0.09 | .005 | 1,663 | 0.04 | .23 | 1,662 | 0.01 | .82 | 3,207 | 0.04 | .07 | 3,216 | 0.02 | .23 | 3,216 | 0.02 | .31 |
| rs12444979 | GPRC5B | 1,630 | 0.02 | .46 | 1,663 | 0.06 | .03 | 1,662 | 0.06 | .01 | 3,207 | 0.02 | .32 | 3,216 | 0.00 | .90 | 3,216 | 0.01 | .51 |
| rs2241423 | MAP2K5 | 1,630 | 0.08 | .01 | 1,663 | 0.04 | .21 | 1,662 | 0.00 | .99 | 3,207 | −0.01 | .87 | 3,216 | −0.02 | .23 | 3,216 | −0.02 | .21 |
| rs543874 | SEC16B | 1,630 | 0.08 | .02 | 1,663 | 0.05 | .08 | 1,662 | 0.04 | .09 | 3,207 | −0.01 | .74 | 3,216 | −0.01 | .55 | 3,216 | −0.01 | .46 |
| Score | 1,630 | 0.18 | <.0001 | 1,663 | 0.12 | <.0001 | 1,662 | 0.11 | <.0001 | 3,207 | −0.02 | .40 | 3,216 | −0.01 | .77 | 3,216 | 0.00 | .80 | |
| % Body Fat | Visceral Adipose Tissue, cm2 | Subcutaneous Adipose Tissue, cm2 | % Body Fat | Visceral Adipose Tissue, cm2 | Subcutaneous Adipose Tissue, cm2 | ||||||||||||||
| rs1558902 | FTO | 1,600 | 0.03 | .44 | 1,604 | 0.01 | .63 | 1,574 | 0.05 | .06 | 2,418 | 0.02 | .45 | 3,172 | 0.01 | .79 | 3,172 | 0.01 | .15 |
| rs2867125 | TMEM18 | 1,600 | 0.03 | .35 | 1,604 | 0.01 | .80 | 1,574 | 0.04 | .15 | 2,418 | −0.04 | .20 | 3,172 | −0.01 | .75 | 3,172 | −0.01 | .76 |
| rs571312 | MC4R | 1,600 | 0.04 | .27 | 1,604 | −0.03 | .34 | 1,574 | 0.04 | .19 | 2,418 | 0.03 | .35 | 3,172 | 0.01 | .67 | 3,172 | 0.01 | .23 |
| rs10938397 | GNPDA2 | 1,600 | 0.09 | .01 | 1,604 | 0.01 | .61 | 1,574 | 0.09 | .001 | 2,418 | −0.01 | .65 | 3,172 | 0.00 | .97 | 3,172 | 0.00 | .05 |
| rs10767664 | BDNF | 1,600 | −0.02 | .61 | 1,604 | −0.02 | .41 | 1,574 | 0.03 | .22 | 2,418 | 0.01 | .65 | 3,172 | 0.02 | .32 | 3,172 | 0.02 | .01 |
| rs2815752 | NEGR1 | 1,600 | 0.00 | .93 | 1,604 | −0.01 | .65 | 1,574 | 0.01 | .70 | 2,418 | 0.04 | .21 | 3,172 | 0.01 | .61 | 3,172 | 0.01 | .05 |
| rs7359397 | SH2B1 | 1,600 | −0.02 | .63 | 1,604 | −0.01 | .77 | 1,574 | 0.01 | .79 | 2,418 | 0.00 | .91 | 3,172 | 0.00 | .96 | 3,172 | 0.00 | .007 |
| rs12444979 | GPRC5B | 1,600 | 0.07 | .05 | 1,604 | 0.03 | .25 | 1,574 | 0.03 | .30 | 2,418 | 0.01 | .84 | 3,172 | −0.01 | .59 | 3,172 | −0.01 | .58 |
| rs2241423 | MAP2K5 | 1,600 | 0.00 | .92 | 1,604 | 0.01 | .63 | 1,574 | 0.01 | .63 | 2,418 | 0.02 | .59 | 3,172 | 0.02 | .35 | 3,172 | 0.02 | .36 |
| rs543874 | SEC16B | 1,600 | 0.03 | .40 | 1,604 | 0.00 | .92 | 1,574 | 0.05 | .08 | 2,418 | −0.04 | .22 | 3,172 | −0.02 | .38 | 3,172 | −0.02 | .74 |
| Score | 1,600 | 0.08 | .02 | 1,604 | 0.01 | .82 | 1,574 | 0.12 | <.0001 | 2,418 | 0.00 | .94 | 3,172 | 0.00 | .96 | 3,172 | 0.00 | .59 | |
Note. Linear regression, values adjusted for age, sex, and study site (site adjustment only in Health ABC).