Table 4.

Association of BMI-Related SNPs and Anthropometric Traits in African Americans

SNP	Nearest Gene	Health ABC
		Midlife Weight, kg			Weight, kg			BMI, kg/m2			% Body Fat			Visceral Adipose Tissue, cm2			Subcutaneous Adipose Tissue, cm2
		N	Allele Effect Size (β)	p	N	Allele Effect Size (β)	p	N	Allele Effect Size (β)	p	N	Allele Effect Size (β)	p	N	Allele Effect Size (β)	p	N	Allele Effect Size (β)	p
rs1558902	FTO	1,080	0.02	.54	1,139	−0.02	.48	1,139	−0.05	.11	1,099	−0.11	.84	1,096	0.03	.32	1,055	−0.02	.53
rs2867125	TMEM18	1,080	0.02	.58	1,139	−0.02	.49	1,139	−0.02	.61	1,099	−0.02	.71	1,096	−0.07	.02	1,055	−0.02	.59
rs571312	MC4R	1,080	0.01	.75	1,139	0.02	.45	1,139	0.03	.29	1,099	0.08	.08	1,096	0.03	.32	1,055	0.04	.32
rs10938397	GNPDA2	1,080	0.05	.16	1,139	0.02	.61	1,139	0.02	.52	1,099	0.00	.95	1,096	−0.01	.67	1,055	0.02	.62
rs10767664	BDNF	1,080	0.04	.18	1,139	0.00	.99	1,139	0.00	.95	1,099	−0.04	.41	1,096	−0.05	.10	1,055	0.00	.98
rs2815752	NEGR1	1,080	−0.01	.69	1,139	−0.03	.35	1,139	−0.02	.54	1,099	−0.03	.57	1,096	−0.03	.35	1,055	−0.01	.71
rs543874	SEC16B	1,080	0.09	.004	1,139	0.06	.05	1,139	0.04	.15	1,099	0.03	.53	1,096	0.02	.55	1,055	0.03	.36
Score		1,080	0.08	.02	1,139	0.01	.67	1,139	0.01	.88	1,099	0.02	.65	1,096	−0.02	.59	1,055	0.01	0.72

Note. Linear regression, values adjusted for age, sex, and study site (site adjustment only in Health ABC).