Table 2.

Change in Cardiometabolic Risk Factors by Change in Body Weight and Composition

	Weight (kg)			Fat Mass (kg)			Waist Circumference (cm)
Variables	Risk Factor Change	SE	p Value	Risk Factor Change	SE	p Value	Risk Factor Change	SE	p Value
Systolic blood pressure (mm Hg)	0.44	0.23	.06	0.68	0.31	.03	0.36	0.24	.14
Diastolic blood pressure (mm Hg)	0.08	0.15	.60	0.19	0.20	.34	0.23	0.16	.16
Total cholesterol (mg/dL)	0.92	0.41	.03	1.87	0.51	<.001	0.69	0.42	.10
LDL cholesterol (mg/dL)	0.58	0.35	.11	1.14	0.44	.01	0.51	0.37	.17
HDL cholesterol (mg/dL)	–0.08	0.14	.59	–0.05	0.18	.80	–0.04	0.12	.75
Triglycerides (mg/dL)	1.75	0.50	<.01	2.70	0.67	<.001	1.13	0.53	.04
LDL–HDL ratio	0.02	0.01	.07	0.34	0.20	.09	0.16	0.20	.43
Glucose (mg/dL)	0.41	0.18	.02	0.03	0.01	.01	0.01	0.01	.30
Insulin (µIU/mL)	0.45	0.08	<.01	0.53	0.10	<.001	0.33	0.08	<.001
HOMA (mg/dL × µU/mL)	2.10	0.35	<.01	2.27	0.48	<.001	1.58	0.40	<.001

Notes: HDL = high-density lipoprotein; HOMA = homeostatic model assessment of insulin resistance; LDL = low-density lipoprotein; M = mean; SE = standard error.

Model-adjusted estimates control for age, race, baseline fat mass, randomization arm, and baseline and postintervention risk factor value. Values for risk factor change are given per 1kg increase in weight.