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. Author manuscript; available in PMC: 2013 Jun 15.
Published in final edited form as: Aquat Toxicol. 2012 Mar 3;0:134–141. doi: 10.1016/j.aquatox.2012.02.025

Figure 1.

Figure 1

(A) Predicted amino acid sequence alignment of the two Coho GPx4 isoform with other fish and mammalian GPx4s. The selenocysteine residue is indicated as U in sequence. The three boxes highlight conserved residues at selenocysteine (U), glutamine (Q) and tryptophan (W). Black shading indicates completely conserved residues and grey shading indicates similar residues (similarity threshhold fraction ≥0.7). The arrow indicates the second translational initiation site. Mitochondrial targeting sequences are underlined. (B) Phylogenetic rooted-tree showing the relationship of Coho GPx4 with other fish and mammalian GPx4s. GenBank accession numbers are shown in parentheses. Graph generated from San Diego Biology Workbench 3.2.