Table 3.
Case–control frequencies of the alleles and genotypes of the polymorphisms onFGF12,VCL,CX43andVAX1
| HWE* (p value) | Control Group (%) | CL ± P Group (%) | ORallele(95% CI) p value | CLO Group (%) | ORallele(95% CI) p value | CLP Group (%) | ORallele(95% CI) p value | |
|---|---|---|---|---|---|---|---|---|
|
FGF12 |
|
|
|
|
|
|
|
|
| rs6790664 |
|
|
|
|
|
|
|
|
| Allele (A/C) |
0.79 |
50.5/49.5 |
50.5/49.5 |
1.00 (0.80-1.24) |
55.3/44.7 |
0.83 (0.61-1.12) |
48/52 |
1.11 (0.87-1.41) |
| Genotype (AA/AC/CC) |
|
25.2/50.6/24.2 |
24.7/51.7/23.6 |
0.50 |
28.6/53.4/18 |
0.28 |
22.6/50.7/26.7 |
0.56 |
| rs11717284 |
|
|
|
|
|
|
|
|
| Allele (A/T) |
0.42 |
51.5/48.5 |
55.5/44.5 |
0.85 (0.68-1.06) |
49/51 |
1.10 (0.81-1.50) |
59/41 |
0.74 (0.58-0.95) |
| Genotype (AA/AT/TT) |
|
27.6/47.9/24.5 |
30.5/50.1/19.4 |
0.36 |
22.1/53.9/24 |
0.22 |
34.9/48.2/16.9 |
0.91 |
| rs1464942 |
|
|
|
|
|
|
|
|
| Allele (A/T) |
0.06 |
27.8/72.2 |
29.6/70.4 |
0.91 (0.72-1.16) |
31/69 |
0.85 (0.61-1.19) |
28.9/71.1 |
0.94 (0.72-1.24) |
| Genotype (AA/AT/TT) |
|
9.6/36.4/54 |
8.7/41.8/49.5 |
0.74 |
8.6/44.8/46.6 |
0.59 |
8.8/40.2/51 |
0.50 |
| rs12106855 |
|
|
|
|
|
|
|
|
| Allele (A/G) |
0.15 |
42.1/57.9 |
40.8/59.2 |
1.05 (0.85-1.31) |
43.3/56.7 |
0.95 (0.69-1.29) |
39.3/60.7 |
1.12 (0.87-1.43) |
| Genotype (AA/AG/GG) |
|
19.5/45.2/35.3 |
17.2/47/35.8 |
0.23 |
17.1/52.4/30.5 |
0.22 |
17.3/44.1/38.6 |
0.53 |
| rs1875735 |
|
|
|
|
|
|
|
|
| Allele (C/G) |
0.14 |
46.1/53.9 |
46.8/53.2 |
0.97 (0.78-1.20) |
44.8/55.2 |
1.06 (0.77-1.43) |
48/52 |
0.93 (0.72-1.18) |
| Genotype (CC/CG/GG) |
|
23.1/46/30.9 |
23.4/47/29.6 |
0.44 |
21/47.6/31.4 |
0.28 |
24.6/46.7/28.7 |
0.76 |
| VCL |
|
|
|
|
|
|
|
|
| rs4746172 |
|
|
|
|
|
|
|
|
| Allele (C/T) |
0.89 |
27.2/72.8 |
27.2/72.8 |
1.00 (0.78-1.27) |
24.3/75.7 |
1.16 (0.82-1.66) |
28.7/71.3 |
0.93 (0.71-1.22) |
| Genotype (CC/CT/TT) |
|
7.5/39.3/53.2 |
7/40.4/52.6 |
0.83 |
2.9/42.8/54.3 |
0.92 |
9.2/39/51.8 |
0.59 |
| rs10762573 |
|
|
|
|
|
|
|
|
| Allele (A/C) |
0.46 |
33.9/66.1 |
32.8/67.2 |
1.05 (0.83-1.32) |
34.3/65.7 |
0.98 (0.71-1.35) |
32/68 |
1.09 (0.84-1.42) |
| Genotype (AA/AC/CC) |
|
10.6/46.5/42.9 |
12.7/40.2/47.1 |
0.94 |
16.2/36.2/47.6 |
0.57 |
10.8/42.2/47 |
0.92 |
| rs2131960 |
|
|
|
|
|
|
|
|
| Allele (A/C) |
0.45 |
62.6/34.4 |
67.9/32.1 |
0.90 (0.72-1.13) |
68.8/31.2 |
0.87 (0.62-1.21) |
67.5/32.5 |
0.92 (0.71-1.19) |
| Genotype (AA/AC/CC) |
|
42.1/46.9/11 |
47.5/40.8/11.7 |
0.62 |
50/37.5/12.5 |
0.23 |
46.1/42.6/11.3 |
0.95 |
| CX43 |
|
|
|
|
|
|
|
|
| rs11961755 |
|
|
|
|
|
|
|
|
| Allele (A/G) |
0.73 |
20.4/79.6 |
21.9/78.1 |
0.91 (0.70-1.19) |
21.4/78.6 |
0.94 (0.64-1.36) |
22/78 |
0.90 (0.67-1.22) |
| Genotype (AA/AG/GG) |
|
4.4/31.9/63.7 |
4.4/35/60.6 |
0.68 |
2.9/37.1/60 |
0.90 |
5.2/33.8/61 |
0.74 |
| rs12197797 |
|
|
|
|
|
|
|
|
| Allele (C/G) |
0.70 |
79/21 |
79/21 |
0.99 (0.76-1.29) |
78.7/21.3 |
1.02 (0.70-1.49) |
79.3/20.7 |
0.98 (0.72-1.33) |
| Genotype (CC/CG/GG) |
|
62.7/32.5/4.8 |
61.6/35/3.4 |
0.94 |
59.2/38.8/2 |
0.97 |
62.8/33/4.2 |
0.94 |
| VAX1 |
|
|
|
|
|
|
|
|
| rs7086344 |
|
|
|
|
|
|
|
|
| Allele (C/T) |
0.23 |
82/18 |
82.5/17.5 |
0.96 (0.73-1.27) |
82.4/17.6 |
0.97 (0.65-1.45) |
82.6/17.4 |
0.96 (0.69-1.32) |
| Genotype (CC/CT/TT) |
|
68/27.8/4.2 |
69.7/25.7/4.6 |
0.12 |
66.7/31.4/1.9 |
0.63 |
71.3/22.6/6.1 |
0.16 |
| rs10787760 |
|
|
|
|
|
|
|
|
| Allele (A/G) |
0.11 |
63.6/36.4 |
62.7/37.3 |
1.04 (0.83-1.290 |
61.9/38.1 |
1.07 (0.78-1.47) |
63/37 |
1.02 (0.79-131) |
| Genotype (AA/AG/G) |
|
42.3/42.6/15.1 |
39.7/46/14.3 |
0.42 |
40/43.8/16.2 |
0.85 |
39.5/47.1/13.4 |
0.46 |
| rs6585429 |
|
|
|
|
|
|
|
|
| Allele (A/G) |
0.09 |
26.3/73.7 |
30.4/69.6 |
0.82 (0.64-1.04) |
32/68 |
0.75 (0.54-1.06) |
29.5/70.5 |
0.85 (0.65-1.12) |
| Genotype (AA/AG/GG) |
|
8.6/35.4/56 |
9.8/41.2/49 |
0.43 |
11.6/40.8/47.6 |
0.46 |
8.7/41.5/49.8 |
0.72 |
| rs1871345 |
|
|
|
|
|
|
|
|
| Allele (C/T) |
0.06 |
76/24 |
75.6/24.4 |
1.02 (0.79-1.31) |
74.3/25.7 |
1.09 (0.77-1.56) |
76.3/23.7 |
0.98 (0.74-1.31) |
| Genotype (CC/CT/TT) |
|
59.5/32.9/7.6 |
56.6/38/5.4 |
0.96 |
55.4/37.8/6.8 |
0.56 |
57.2/38.1/4.7 |
0.85 |
| rs751231 |
|
|
|
|
|
|
|
|
| Allele (A/C) |
0.34 |
81.5/18.5 |
80.1/19.9 |
1.09 (0.83-1.43) |
78.9/21.1 |
1.18 (0.80-1.72) |
80.8/19.2 |
1.04 (0.76-1.42) |
| Genotype (AA/AC/CC) |
|
67.1/28.8/4.1 |
63.3/33.7/3 |
0.83 |
61.5/34.6/3.9 |
0.16 |
64.3/33.1/2.6 |
0.91 |
| rs751233 |
|
|
|
|
|
|
|
|
| Allele (A/G) |
0.47 |
17/83 |
19.5/80.5 |
0.84 (0.64-1.11) |
20.7/79.3 |
0.78 (0.53-1.15) |
18.9/81.1 |
0.87 (0.64-1.20) |
| Genotype (AA/AG/GG) | 3.4/27.1/69.5 | 3.7/31.6/64.7 | 0.58 | 3.8/33.7/62.5 | 0.24 | 3.6/30.6/65.8 | 0.83 |
HWE: Hardy Weinberg equilibrium, CL ± P: cleft lip with or without cleft palate, CLO: cleft lip only, CLP: cleft lip and palate.