Table 4.
Distribution of the risk haplotypes
| Tagging polymorphisms | Candidate risk haplotype* | Control group | CL ± P group | P value | CLO group | P value | CLP group | P value |
|---|---|---|---|---|---|---|---|---|
|
FGF12 |
A-C-T |
34.9% |
35.5% |
0.46 |
32.1% |
0.73 |
37.2% |
0.65 |
| rs11717284, rs6790664, rs1464942 | ||||||||
|
FGF12 |
A-G-G |
3.9% |
2.7% |
0.40 |
2.4% |
0.77 |
2.9% |
0.81 |
| rs1464942, rs12106855, rs1875753 | ||||||||
|
VCL |
C-A-T |
53.5% |
56.8% |
0.44 |
58.3% |
0.37 |
55.8% |
0.59 |
| rs10762573, rs2131960, rs4746172 | ||||||||
|
CX43 |
C-G |
78.8% |
77.6% |
0.78 |
78.1% |
0.89 |
77.4% |
0.75 |
| rs12197797, rs11961755 | ||||||||
|
VAX1 |
G-A-C |
2.6% |
6.7% |
0.026 |
6.9% |
0.19 |
6.7% |
0.033 |
| rs10787760, rs6585429, rs1871345 | ||||||||
*Risk haplotypes of FGF12, VCL and CX43 were based on Jugessur et al. (2011).
CL ± P: cleft lip with or without cleft palate, CLO: cleft lip only, CLP: cleft lip and palate.