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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: J Immunol. 2013 Apr 24;190(11):5526–5533. doi: 10.4049/jimmunol.1201885

Figure 3. In vivo generated plasma cells are altered in Lgals1−/− mice.

Figure 3

WT and Lgals1−/− mice were immunized with NP-KLH in alum. The numbers of NP-specific IgM and IgG1 ASC in the spleen (A) and bone marrow (B) of WT and Lgals1−/− mice were evaluated by ELISPOT. Studies were performed in triplicate with at least 5 mice per group. Affinity maturation was measured by the NP3 (high)/NP23 (low) affinity ASC ratio in spleen (C) and in bone marrow (D) at day 21 and day 40. Data are means of 2 independent experiments with 4 mice per group. Open and black squares correspond to WT and Lgals1−/− mice, respectively.

* and ** indicate significance versus WT mice with p<0.05 and <0.005 respectively.