Table 3.

Biopharmaceutics Classification System of medications [31]

	High solubility	Low solubility
High permeability	Class I	Class II
	High solubility	Low solubility
	High permeability	High permeability
	Transporter effects minimal	Efflux (flows out) transporter effects predominate
	Examples: Atropine, Caffeine, Diazepam, Glucose, Levodopa, Prednisolone	Examples: Digoxin, Ibuprofen, Warfarin
Low permeability	Class III	Class IV
	High solubility	Low solubility
	Low permeability	Low permeability
	Absorptive transporter effects predominate	Absorptive and efflux transporter effects could be important
	Examples: Atenolol, Captopril, Cimetidine, Acyclovir, Penicillin, Amoxicillin, Erythromycin	Examples: Amphotericin B, Chlothalidone, Neomycin