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. 2013 May 21;8(5):e64121. doi: 10.1371/journal.pone.0064121

Figure 7. Mean histology scores from hamsters challenged with C. difficile strains.

Figure 7

C. difficile CD1342 (filled columns), M68 (open columns) or BI-7 (checked column) at either 1-, 3- & 11-d.p.c (A) or if the hamsters succumbed to infection (B). Caecal pathology was graded by neutrophil margination, haemorrhagic congestion, hyperplasia and percent barrier involvement from at least four animals. Typical caecal histology from hamsters challenged with either CD1342 (at 1-d.p.c. - C), M68 (at 3-d.p.c. - D) or BI-7 (at ∼26 h - E). Red arrows denotes unclotted red blood cells within the villus structure; black arrows denotes epithelial barrier destruction & green arrows denotes transmural neutrophil infiltrate.