Table 2. Maximum inhibition, IC₅₀ and EC₅₀ for the effects of 17-BMP on LPS-stimulated macrophage cytokine production.

	Maximum % Inhibition				IC50 (nM)			EC50 (nM)
	NS	S	COPD	p [A]	NS	S	COPD	NS	S	COPD
CXCL8	58.3 (14.6)	66.8 (8.4)	71.0 (14.8)	0.67	16.65	4.55	2.04	0.2	0.1	0.09
TNFa	78.4 (18.9)	85.8 (7.1)	81.7 (12.8)	0.08	0.5	0.21	0.21	0.08	0.08	0.06
IL-6	80.5 (14.7)	76.0 (18.0)	72.0 (15.3)	0.41	0.49	0.46	0.36	0.1	0.08	0.03
p[B]	0.0004	0.0156	0.0023

The mean (SD) percentage inhibition at 100 nM (maximal inhibition). One-way ANOVA were performed between patient groups (p values in column [A]) and between cytokines (p value in row [B]). IC₅₀ (concentration required to inhibit LPS effect by 50%) and EC₅₀ values (concentration required to elicit 50% of the maximal effect) of 17-BMP for each cytokine are shown. COPD (n = 25), S (n = 11) and NS (n = 8).