Table I.

Activation foci for encoding/learning vs. distractor task

Activation area	Healthy subjectsa		Bipolar disorder
	z	x, y, z	z	x, y, z
Left and right medial temporal regions
Left Parahippocampal Gyrus (BA 28, 29 and 35)	5.64	−24, −28, −8	4.28	−26, −30, −6
Left Hippocampus	3.69	−34, −18, −20	4.59	−26, −32, −2
Left Amygdala	3.31	−32, −4, −16	–
Right Parahippocampal Gyrus (BA 27, 28 and 35)	6.49	24, −30, −6	5.01	18, −32, −6
Right Hippocampus	3.18	26, −10, −20	–
Right Amygdala	3.03	24, −6, −20	–
Left lateral prefrontal cortex
Middle Frontal Gyrus (BA 46)	5.67	−46, 28, 20	4.73	−44, 18, 26
Middle Frontal Gyrus (BA 9)	5.21	−38, 4, 26	3.74	−48, 14, 22
Middle Frontal Gyrus (BA 6 & 8)	4.75	−48, 4, 46	4.28	−44, 2, 42
Inferior Frontal Gyrus (BA 47)	4.81	−50, 36, −2	4.51	−46, 42, −2
Right Lateral Prefrontal Cortex
Middle Frontal Gyrus (BA 46)	5.58	42, 28, 14	4.42	44, 32, 18
Inferior and Middle Frontal Gyrus (BA 9)	3.62	42, 16, 28	3.94	46, 6, 30
Precentral Gyrus (BA 6)	4.99	38, 6, 22	3.89	36, 6, 26
Left medial prefrontal cortex
Cingulate Gyrus (BA 32)	5.36	−8, 24, 36	4.09	−6, 16, 44
Superior Frontal Gyrus (BA 6 & 8)	6.01	−6, 14, 46	3.85	−8, 18, 58
Left and right parietal cortex
Left Precuneus (BA 19)	5.24	−30, −72, 36	3.28	−34, −68, 38
Left Inferior and Superior Parietal Lobule (BA 7 and 39)	4.29	−28, −68, 24	3.51	−36, −64, 40
Right Precuneus (BA 19)	5.67	34, −64, 42	–
Right Angular Gyrus (BA 39)	5.46	32, −62, 34	–
Bilateral occipital lobe and cerebellum
Middle and Inferior Occipital Gyri (BA 18)	6.47	30, −86, −14	5.15	−32, −96, 2
Lingual Gyrus (BA 17 and 18)	6.18	−18, −102, −16	5.82	0, −76, −4
Fusiform Gyrus (BA 18 and 19)	6.03	26, −96, −14	5.33	22, −88, −14
Cerebellum (Declive, Culmen and Tuber)	6.68	34, −84, −22	6.01	−28, −72, −22
Left lateral temporal cortex
Middle Temporal Gyrus (BA 21)	–		4.39	−58, −36, −2

^aValue and Talairach coordinate for the maximum z‐statistic in that area for each group separately.