Table 1. Patient and tumor characteristics.
| BRCA1 (n = 33) | BRCA2 (n = 22) | Sporadic (n = 128) | |||
| Estrogen receptor | |||||
| ER+ | 14 | 20 | 107 | ||
| ER− | 19 | 2 | 21 | ||
| Progesterone receptor | |||||
| PR+ | 7 | 16 | 79 | ||
| PR− | 26 | 6 | 49 | ||
| HER2 status | |||||
| HER2+ | 3 | 1 | 21 | ||
| HER2− | 30 | 21 | 107 | ||
| Lymph node | |||||
| LN+ | 15 | 14 | 51 | ||
| LN− | 16 | 7 | 75 | ||
| NA | 2 | 1 | 2 | ||
| Tumor size | |||||
| Mean tumor size, mm (±SD) | 23 (±10) | 25 (±13) | 25 (±16) | ||
| Histologic grade | |||||
| Grade 1 | 3 | 2 | 32 | ||
| Grade 2 | 7 | 11 | 48 | ||
| Grade 3 | 18 | 7 | 29 | ||
| NA | 5 | 2 | 19 | ||
| Tumor type | |||||
| Invasive ductal carcinoma | 28 | 19 | 105 | ||
| Invasive lobular carcinoma | 1 | 2 | 12 | ||
| Mucinous carcinoma | 0 | 0 | 2 | ||
| Medullary carcinoma | 2 | 0 | 1 | ||
| Tubular carcinoma | 0 | 0 | 3 | ||
| Metaplastic carcinoma | 0 | 0 | 0 | ||
| Other | 0 | 0 | 2 | ||
| NA | 2 | 1 | 3 | ||
| Age | |||||
| Median age, years (range) | 42 (25–74) | 43.5 (28–72) | 61 (27–95) | ||
| <50 years | 21 | 15 | 21 | ||
| ≥50 years | 12 | 7 | 107 | ||
| Menupause status | |||||
| Premenopausal | 20 | 15 | 30 | ||
| Perimenopausal | 0 | 1 | 15 | ||
| Postmenopausal | 12 | 5 | 78 | ||
| Other | 0 | 0 | 2 | ||
| NA | 1 | 1 | 3 | ||