Table 3. Cross-platform validation of the gene signatures.
Gene signature | No. of samples | Overlapping genes | Sensitivity (TP) | Specificity (TN) | Accuracya | p-valueb |
Basal BRCA1 signature | 20 vs. 10 | 95/110 | 0.95 (19) | 0.90 (9) | 0.93 | 6.7×10−6 |
LumB BRCA2 signature | 16 vs. 46 | 92/100 | 0.94 (15) | 0.96 (44) | 0.96 | 2.2×10−11 |
Validation of the basal BRCA1 signature and lumB BRCA2 signature were performed using samples analyzed by in-house spotted microarrays. Classification performances were assessed by leave-one-out cross-validation. TP, true positive; TN, true negative.
Mean balanced accuracy.
Fisher's exact test.