Table 4. Validation of gene signatures in independent datasets.

	No. of samples	Overlapping genes	Sensitivity (TP)	Specificity (TN)	Accuracya	p-valueb
Basal BRCA1 signature
NKI dataset	16 vs. 18	76/110	0.81 (13)	0.83 (15)	0.82	3.9×10−4
Jönsson dataset	13 vs. 34	69/110	0.93 (12)	0.82 (28)	0.87	3.9×10−6
LumB BRCA2 signature
Jönsson dataset	21 vs. 68	77/100	0.90 (19)	0.83 (57)	0.87	7.3×10−10

The basal BRCA1 signature and lumB BRCA2 signature was validated in two public available datasets. Classification performances were assessed by leave-one-out cross-validation. TP, true positive; TN, true negative.

^aMean balanced accuracy.

^bFisher's exact test.