Table 4. Validation of gene signatures in independent datasets.
No. of samples | Overlapping genes | Sensitivity (TP) | Specificity (TN) | Accuracya | p-valueb | |
Basal BRCA1 signature | ||||||
NKI dataset | 16 vs. 18 | 76/110 | 0.81 (13) | 0.83 (15) | 0.82 | 3.9×10−4 |
Jönsson dataset | 13 vs. 34 | 69/110 | 0.93 (12) | 0.82 (28) | 0.87 | 3.9×10−6 |
LumB BRCA2 signature | ||||||
Jönsson dataset | 21 vs. 68 | 77/100 | 0.90 (19) | 0.83 (57) | 0.87 | 7.3×10−10 |
The basal BRCA1 signature and lumB BRCA2 signature was validated in two public available datasets. Classification performances were assessed by leave-one-out cross-validation. TP, true positive; TN, true negative.
Mean balanced accuracy.
Fisher's exact test.