. Author manuscript; available in PMC: 2014 Apr 1.

Published in final edited form as: Ann Neurol. 2013 Feb 19;73(4):472–480. doi: 10.1002/ana.23816

Table 2.

Descriptive Characteristics of Participants according to Stage or Group

Characteristic	Stage 0 (n = 191)	Stage 1 (n = 68)	Stage 2 (n = 56)	Stage 3 (n = 13)	sNAP (n = 102)
Age, years, median (IQR)	76 (73, 79) ^*^†	80 (75, 82)	80 (78, 82)	82 (80, 84)	80 (76, 84)
Women, no. (%)	94 (49)	34 (50)	19 (34)	6 (46)	41 (40)
Education, years, median (IQR)	13 (12, 16)	14 (12, 16)	15 (12, 18)	13 (12, 15)	14 (12, 16)
APOE ε4 carrier, no.(%)	43 (23) ^†	30 (44) ^*	25 (45) ^*	7 (54) ^*	14 (14) ^†
MMSE, median (IQR)	29 (28, 29) ^†	28 (27, 29)	28 (27, 29)	27 (27, 28) ^*	28 (27, 29)
Cognitive Z-scores, median (IQR)
Global	0.84 (0.22, 1.40) ^*^†	0.38 (−0.12, 1.29)^*^†	0.35 (−0.26, 0.80)	−1.22 (−1.32, −0.99) ^*	0.13 (−0.52, 0.96)
Memory	0.78 (0.01, 1.42) ^*^†	0.63 (−0.37, 1.31) ^†	0.37 (−0.48, 0.93)	−1.23 (−1.36, −0.75) ^*	0.26 (−0.39, 1.02)
Language	0.58 (0.01, 1.11) ^*^†	0.36 (−0.25, 0.79)	0.16 (−0.35, 0.72)	−0.90 (−1.12, −0.15) ^*	0.09 (−0.50, 0.85)
Executive	0.69 (0.13, 1.18) ^*^†	0.42 (−0.17, 1.26) ^†	0.15 (−0.38, 0.79)	−0.64 (−0.98, −0.29) ^*	0.04 (−0.60, 0.93)
Visuospatial	0.73 (0.10, 1.27) ^*^†	0.56 (0.00, 1.25) ^*	0.53 (−0.16, 0.96)	−1.43 (−1.71, −0.92) ^*	0.20 (−0.51, 0.74)
PIB global cortical ratio	1.33 (1.29, 1.38) ^†	1.86 (1.66, 2.07) ^*	1.93 (1.67, 2.26) ^*	2.35 (1.91, 2.81) ^*	1.35 (1.31, 1.39) ^†
AD composite FDG ratio	1.46 (1.40, 1.53) ^*^†	1.42 (1.38, 1.48) ^*^†	1.28 (1.21, 1.32)	1.23 (1.15, 1.27)	1.28 (1.24, 1.33)
Hippocampal volume, adjusted for TIV	0.47 (−0.01, 0.92)^*^†	0.28 (−0.12, 0.75)^*^†	−0.68 (−1.02, 0.10)	−0.87 (−1.17, −0.52)	−0.62 (−1.06, −0.14)

sNAP= suspected non-Alzheimer pathway; IQR = interquartile range; MMSE = Mini-mental State examination; PIB = Pittsburgh compound B; FDG = fluorodeoxyglucose; TIV = total intracranial volume

differs from sNAP group, p<.01;

^†

differs from preclinAD stages 2+3 combined, p<.01