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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Eur J Pharm Biopharm. 2012 Dec 8;84(2):335–344. doi: 10.1016/j.ejpb.2012.11.023

Figure 6.

Figure 6

Expression of proteins (immunohistochemistry) in lung tissues. Representative images of tissue sections stained with antibodies against VEGF, CCL12, MMP3 and HIF1A proteins (10X magnification) and average expression of corresponding proteins. High intensity of the color indicates high protein concentration. Lung fibrosis was induced by intratracheal instillation of 1.5 U/kg of bleomycin. Mice were treated with liposomal PGE2 twice a week for three weeks starting one day later after the bleomycin administration. 1 - Healthy mice (control); 2-Mice instilled with bleomycin (1.5 U/kg); 3 - Mice instilled with bleomycin (1.5 U/kg) and treated by inhalation with liposomal PGE2. Means ± SD from are shown. *P < 0.05 when compared with healthy mice (control). †P < 0.05 when compared with mice instilled with bleomycin.