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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Neurochem. 2013 Apr 2;125(5):756–765. doi: 10.1111/jnc.12231

Figure 6. MAC1 mediates diesel exhaust particle (DEP)-induced loss of dopaminergic neuron function.

Figure 6

The effect of diesel exhaust particles on loss of DA neuron function was compared in mesencephalic neuron-glia cultures from MAC1−/− and MAC1+/+ mice. Lipopolysaccharide (LPS) was used as a positive control for microglia-induced loss of neuronal function and MAC1-specific DA neuron damage. Loss of DA neuron function was measured at 7 days post treatment using the [3H] DA uptake assay. Results are expressed as percent of control and are the mean ± SEM. Samples were run in triplicates and the data are the result of 3 independent experiments (n=3). The raw data (counts per second) for control values range from 1429– 4811 across experimental replicates. An asterisks indicates a significant difference from control (p<0.05) and a “†” indicates a significant difference between the mouse strains (2 Way ANOVA, p<0.05; strain × treatment interaction, p<0.05).