Table 2.
Association results of 19 kidney SNPs with clinical vascular traits in individuals of European descent from the ICBP and CARDIoGRAM consortia.
| Kidney SNP | Nearest Gene | Coded (risk) allele | SBP | DBP | CAD | |||
|---|---|---|---|---|---|---|---|---|
| β | p-value | β | p-value | OR (CI) | p-value | |||
| rs10109414 | STC1 | T | -0.054 | 0.6 | 0.07 | 0.3 | 0.99 [0.97 - 1.02] | 0.9 |
| rs11959928 | DAB2 | A | 0.009 | 0.9 | -0.009 | 0.9 | 1.01 [0.98 - 1.04] | 0.3 |
| rs12460876 | SLC7A9 | T | 0.169 | 0.1 | 0.074 | 0.2 | 1.01 [0.97 - 1.03] | 0.6 |
| rs1260326 | GCKR | C | -0.102 | 0.3 | -0.019 | 0.8 | 0.97 [0.94 - 1.00] | 0.1 |
| rs12917707 | UMOD | G | 0.353 | 0.005 | 0.244 | 0.002 | 1.01 [0.97 - 1.051 | 0.4 |
| rs13538 | ALMS1 | A | -0.096 | 0.4 | -0.13 | 0.1 | 0.95 [0.91 - 0.981 | 0.004 |
| rs1394125 | UBE2Q2 | A | 0.112 | 0.3 | 0.021 | 0.8 | NA** | NA** |
| rs17319721 | SHROOM3 | A | -0.143 | 0.1 | -0.042 | 0.5 | 1.01 [0.98 - 1.03] | 0.6 |
| rs1801239 | CUBN | T | -0.017 | 0.9 | 0.038 | 0.7 | 1.01 [0.95 - 1.05] | 0.8 |
| rs267734 | ANXA9 | T | -0.047 | 0.7 | -0.028 | 0.7 | 0.99 [0.96 - 1.03] | 0.9 |
| rs347685 | TFDP2 | A | 0.035 | 0.7 | -0.088 | 0.2 | 1.02 [0.99 - 1.04] | 0.2 |
| rs4744712 | PIP5K1B | A | -0.002 | 0.98 | 0.035 | 0.6 | 1.01 [0.98 - 1.04] | 0.3 |
| rs626277 | DACH1 | A | -0.038 | 0.7 | -0.022 | 0.7 | 1.01 [0.96 - 1.03] | 0.9 |
| rs6420094 | SLC34A1 | G | 0.086 | 0.5 | 0.097 | 0.2 | NA** | NA** |
| rs653178 | SH2B3 | C | 0.605 | 9.3E-10*** | 0.48 | 1.64E-14*** | 1.08 [1.04 - 1.11] | 2.2E-06*** |
| rs7805747 | PRKAG2 | A | 0.359 | 0.02 | 0.178 | 0.1 | NA** | NA** |
| rs81204* | KCNQ1 | C | -0.032 | 0.8 | 0.04 | 0.6 | 1.01 [0.98 - 1.05] | 0.4 |
| rs881858 | VEGFA | A | 0.009 | 0.9 | 0.172 | 0.02 | 1.01 [0.96 - 1.03] | 0.9 |
| rs911119 | CST3 | T | -0.177 | 0.1 | -0.107 | 0.2 | 0.99 [0.96 - 1.02] | 0.8 |
NOTE: The clinical vascular traits tested were SBP, DBP, and CAD. Results are presented for the trait-decreasing eGFR allele.
CAD, coronary artery disease; DBP, diastolic blood pressure; rs, reference NSP identifier; SBP, systolic blood pressure; SNP, single nucleotide polymorphism; ICBP (International Consortium for Blood Pressure); CARDIoGRAM (Coronary Artery Disease Genome-wide Replication and Meta-Analysis); OR, odds ratio; CI, confidence interval; eGFR, estimated glomerular filtration rate; NA, not available.
The rs163160 SNP was used as a proxy for SBP, DBP and CAD (r2=0.81).
These SNPs were not available in the imputed CARDIoGRAM meta-analysis dataset and an adequate proxy was not found.
Significant associations after Bonferroni correction for multiple testing (p ≤ 1.5e-4)