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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Am J Kidney Dis. 2013 Mar 6;61(6):889–898. doi: 10.1053/j.ajkd.2012.12.024

Table 5.

Association of 25 CAD SNPs with kidney traits in individuals of European descent from the CKDGen consortium.

CAD SNP Nearest Gene Coded (risk) allele UACR eGFRcr eGFRcys
β p-value β p-value β p-value
rs11206510 PCSK9 T -0.012 0.3 -0.001 0.5 -0.003 0.4
rs599839 SORT1 A 0.018 0.1 0.003 0.1 0.001 0.6
rs17465637 MIA3 C -0.009 0.7 -0.006 0.4 -0.005 0.4
rs6725887 WDR12 C -0.024 0.1 -0.004 0.04 -0.007 0.04
rs2306374 MRAS C 0.012 0.3 -0.001 0.5 0.003 0.3
rs12526453 PHACTR1 C 0.003 0.8 0.0002 0.9 0.002 0.4
rs3798220 LPA C NA* NA* NA* NA* NA* NA*
rs4977574 CDKN2A, CDKN2B G 0.013 0.1 -0.002 0.2 0.003 0.2
rs1746048 CXCL12 C -0.018 0.2 -0.001 0.7 0.001 0.9
rs3184504 SH2B3 T -0.008 0.4 -0.003 0.01 -0.012 1.06E-07**
rs1122608 LDLR G -0.016 0.1 -0.001 0.5 -0.002 0.5
rs9982601 MRPS6 T 0.006 0.7 -0.001 0.6 0.005 0.2
rs17114036 PPAP2B A -0.018 0.2 -0.003 0.2 0.001 0.8
rs17609940 ANKS1A G -0.008 0.5 -0.001 0.5 0.0003 0.9
rs12190287 TCF21 C 0.014 0.2 0.002 0.1 -0.004 0.1
rs11556924 ZC3HC1 C -0.015 0.1 -0.001 0.6 -0.002 0.5
rs579459 ABO C -0.018 0.1 0.002 0.3 -0.004 0.1
rs12413409 CYP17A1 G -0.038 0.017 0.003 0.1 -0.0002 0.9
rs964184 ZNF259 G 0.008 0.6 -0.002 0.3 -0.01 0.002
rs4773144 COL4A1 G -0.022 0.02 -0.002 0.1 0.001 0.7
rs2895811 HHIPL1 C 0.006 0.6 -0.001 0.4 -0.001 0.7
rs3825807 ADAMTS7 A 0.002 0.8 0.001 0.5 0.001 0.6
rs216172 SMG6 C -0.008 0.6 0.002 0.4 0.002 0.5
rs12936587 RASD1 G 0.02 0.04 0.003 0.02 0.004 0.1
rs46522 UBE2Z T 0.018 0.046 0.001 0.7 0.002 0.5

Note: The kidney traits tested are UACR, eGFRcr, and eGFRcys. Results are presented in the trait-increasing allele for CAD. CAD, coronary artery disease; SNP, single nucleotide polymorphism; eGFR, estimated glomerular filtration rate; eGFRcr, creatinine-based eGFR; eGFRcys, cystatin C-based eGFR; UACR, urinary albumin-creatine ratio; CKD, chronic kidney disease; NA, not available.

*

This SNP was not available in the imputed CKDGen meta-analysis dataset and an adequate proxy was not found.

**

Significant associations after Bonferroni correction for multiple testing (p ≤ 1.5e-4)