Table 6.

Associations of 10 subclinical atherosclerosis SNPs with kidney traits in individuals of European descent from the CKDGen consortium.

CVD SNP	Nearest Gene	Coded (risk) allele	CVD phenotype	UACR		eGFRcr		eGFRcys
				β	p-value	β	p-value	β	p-value
rs11781551	ZHX2	G	cIMT	-0.005	0.6	-0.0001	0.9	-0.001	0.6
rs445925	APOC1	G	cIMT	-0.01	0.8	-0.007	0.1	-0.001	0.9
rs6601530	PINX1	G	cIMT	-0.017	0.1	0.003	0.03	0.001	0.7
rs7152623	3′-BCL11B	G	PWV	-0.007	0.4	-0.001	0.5	0.001	0.8
rs2287921	RASIP1	C	RVC	0.009	0.3	-0.003	0.1	-0.006	0.01
rs225717	VTA1	T	RVC	0.009	0.4	0.004	0.02	0.001	0.7
rs10774625	SH2B3	A	RVC	-0.008	0.4	-0.003	0.03	-0.013	7.05E-08*
rs17421627	MEF2C	G	RVC	0.002	0.9	0.004	0.1	0.001	0.8
rs3744028	TRIM65	C	WML	-0.01	0.4	0.006	0.0005	-0.0003	0.9
rs1055129	TRIM47	G	WML	-0.011	0.3	0.005	0.002	0.001	0.9

Note: The subclinical CVD SNPs (atherosclerosis SNPs) were previously associated with cIMT, PWV, RVC, and WMLs. The kidney traits tested are UACR, eGFR_cr, and eGFR_cys. Results are presented in the trait-increasing allele for the respective subclinical CVD phenotype.

CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; eGFR_cr, creatinine-based eGFR; eGFR_cys, cystatin C-based eGFR; UACR, urinary albumin-creatine ratio; CKD, chronic kidney disease;; cIMT, carotid intima-media thickness; PWV, pulse-wave velocity; RVC, retinal venular caliber; WML, white matter lesion; SNP, single nucleotide polymorphism

^*Significant associations after Bonferroni correction for multiple testing (p ≤ 1.5e-4).