Table 4.
Metabolite Associations with Complications of Prematurity
| RDS | No (N=237) | Yes (N=364) | Model 1 | Model 2 | Model 3 |
| P-valuea | P-valueb | P-valuec | |||
| PHE | 61.6±18.7 | 72.6±29.9 | 1.7×10−5 | 4.1×10−4 | 0.03 |
| PDA | No (N=536) | Yes (N=133) | Model 1 | Model 2 | Model 3 |
| P-valuea | P-valueb | P-valuec | |||
| LEU | 127.0±91.9 | 159.1±55.7 | 1.0×10−3 | 2.7×10−3 | 0.01 |
| MET | 25.8±20.5 | 33.1±17.9 | 1.2×10−3 | 0.02 | 0.02 |
| PHE | 66.7±30.4 | 77.0±20.8 | 4.7×10−4 | 1.2×10−3 | 9.3×10−4 |
| VAL | 93.6±53.7 | 123.2±48.8 | 3.2×10−4 | 1.0×10−3 | 8.3×10−3 |
| C6-DC | 0.03±0.04 | 0.05±0.09 | 7.8×10−4 | 6.1×10−3 | 0.02 |
Means and SD in uM units.
a
ANOVA model adjusted for major assay change, year of sample collection and adjustment for birth weight and gestational age.
b
ANOVA model adjusted for major assay change, year of sample collection and adjustment for birth weight and gestational age and excluding infants on TPN, twins and infants with congenital anomalies.
c
ANOVA model adjusted for major assay change, year of sample collection, birth weight and gestational age in infants <=32 weeks gestation.