Table 3.

Clinical and gross pathologic features of each case

Case	Without CD				With CD
	1	2	3	4	5
Clinical features
Age, y	72	73	31	80	63
Sex	Male	Female	Male	Female	Male
History of celiac disease	No	No a	No	No	Yes b
Anti-TTG IgA	Not done	Not done	Not done	Not done	Positive
Treatment (CHOP)	Yes	No	Yes	No	Yes
Dead of disease	Yes	Yes	Yes	Yes	Yes
Survival (months)	12	2	7	0	7
Tumor site and gross features
Location	Ileum and jejunum	Jejunum	Jejunum	Small intestine	Small intestine
Mass lesion	Multifocal	Single	Multifocal	Multifocal	Single
Perforation	No	Yes	No	Yes	Yes
Extraintestinal sites of involvement
Adenopathy	No	No	Yes, distant	No	Yes, regional
Bone marrow	Not biopsied	No	No	Not biopsied	No
Hepatosplenomegaly	No	No	No	No	No
Skin lesions	No	None described	None described	No	Dermatitis herpetiformis
Other sites	Lungs	No	Ascites fluid	No	No

^aAfter the diagnosis of EATL, this patient began prednisone therapy for “CD,” despite the lack of a diagnostic biopsy and positive serology. In our study, this patient was also shown to lack the celiac-associated HLA genotype.

^bThe CD was diagnosed 58 years before the lymphoma. The patient had been treated intermittently with steroids in the past and 3 months before his lymphoma began following a gluten-free diet after which his symptoms improved.