Skip to main content
. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Nat Immunol. 2013 Apr 28;14(6):584–592. doi: 10.1038/ni.2585

Figure 3. B6.SJL/NCI and B6.SJL/Tac mice harbor a frameshift mutation in Sox13.

Figure 3

(a) Schematic of the Sox13 gene; exons are indicated in squares and introns by lines (not drawn to scale). The C nucleotide insertion and premature stop codon are indicated with arrows. (b) Sox13 cDNA and amino acid sequence in wild-type (WT, B6/NCI) and Sox13mut/mut (B6.SJL/NCI) mice. The C nucleotide insertion is indicated with an arrow. (c) Quantification of Sox13 mRNA in sorted Vγ4+CD24+ and Vγ4−CD24+ γδ T cells from adult thymi of WT (B6/NCI) and Sox13mut/mut (B6.SJL/NCI) mice, and whole thymus from a WT (B6/NCI) mouse. Real-time PCR data are shown for primer pairs spanning Sox13 exons 6–7 (left), exons 12–13 (center) and exons 1–2 (right). Horizontal and vertical bars represent the mean (± s.d.). *P≤0.05, **P≤0.01. Data are representative of two experiments (sorted γδ T cells) or one experiment (whole thymus).