Figure 1. Dose-dependent effects of OxPAPC and PEIPC on transendothelial electrical resistance.
Human pulmonary artery endothelial cells (HPAECs) were seeded in polycarbonate wells with gold microelectrodes. After 24 hr of culture, HPAEC were stimulated with various concentrations of: A - OxPAPC (2, 5, 10, 25 and 50 µg/ml); or B - PEIPC (1, 2, 3, 5 and 10 µg/ml), and measurements of transendothelial electrical resistance (TER) were monitored over 4 hrs using an electrical cell-substrate impedance sensing system (ECIS). Results are representative of five independent experiments.