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. 2013 May 21;8(5):e63402. doi: 10.1371/journal.pone.0063402

Figure 5. The levels of heme biosynthetic enzymes, heme transporters, and oxygen-utilizing hemoproteins are elevated in various human tumor xenografts.

Figure 5

Lysates from the indicated human tumor xenografts were prepared, and the levels of the indicated proteins were detected by Western blotting. The protein level of β-actin was used for normalization. (A) The protein level of ALAS1 in HCC4017 cells and in various human tumor xenografts. (B) The protein level of HCP1 in HCC4017 cells and in various human tumor xenografts. (C) The protein level of HRG1 in HCC4017 cells and in various human tumor xenografts. (D) The protein level of cytoglobin in HCC4017 cells and in various human tumor xenografts. (E) The protein level of CYP1B1 in HCC4017 cells and in various human tumor xenografts. For statistical analysis, the levels in HCC4017 cells and tumors were compared to the levels in normal cells, by using Welch 2-sample t-test. *, p value <0.05; **, p value <0.005.