Figure 7. Reducing heme availability suppresses lung cancer cell proliferation, colony formation, and migration.

Cells treated with succinyl acetone were also maintained in heme-depleted medium. (A) Reducing heme availability or mitochondrial function preferentially reduces NSCLC cancer cell proliferation. %live cells was calculated by dividing the number of treated cells with the number of untreated cells (seeded with the same number of cells). It shows the relative proliferative rates of treated cells (SA or SnPP) vs. untreated cells (None). (B) Reducing heme availability or mitochondrial function preferentially reduces NSCLC cell colony formation. (C) Reducing heme availability preferentially reduces NSCLC cell migration. For statistical analysis, the levels in cancer cells were compared to the levels in normal cells, by using Welch 2-sample t-test. **, p value <0.005.