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. 2013 May 21;8(5):e63861. doi: 10.1371/journal.pone.0063861

Figure 2. Identification and characterization of a novel GPR119 agonist.

Figure 2

(A) Chemical structure of compound MW1219. Agonist activity of MW1219 was studied in HEK293-hGPR119 cells (B) and control HEK293 cells (C) employed in a reporter gene assay system, respectively. The effect of MW1219 was confirmed in a cAMP accumulation assay using HEK293-hGPR119 cells and control HEK293 cells (D and E). Allosteric activities of MW1219 for OEA were measured in both reporter gene and cAMP assays (F and G). All data points were representatives of three independent experiments, determined in triplicate.