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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: J Immunol. 2013 Mar 29;190(9):4483–4487. doi: 10.4049/jimmunol.1300212

Figure 4. IL-7 is required to maintain mTregs in skin.

Figure 4

Memory Tregs were generated by inducing Ova expression in the skin of K5/TGO/DO11 mice for 30 days and subsequently turning off antigen for > 30 days. Mice were subsequently treated with anti-IL-7Rα blocking antibody or control antibody for 21-28 days. Absolute number of Foxp3+ and Foxp3- DO11 cells in the skin and SDLNs after treatment with anti-IL-7Rα blocking antibody or control antibody are shown. p value from 2-tailed unpaired t test. Results are pooled data from 2 of 3 replicate experiments with > 3 mice per group.