Figure 3.

Simulation of Ca²⁺ sparks and blinks. (A) Simulated Ca²⁺ sparks. The simulated Ca²⁺ spark was generated by the array of RyRs shown in Fig. 4. (B) The corresponding simulated Ca²⁺ blink. Scale bars apply to both A and B. (C) Corresponding spatial profiles of spark and blink fluorescence at the times of their peak and minimum intensities, respectively. The noisy line shows the profile of an experimentally recorded Ca²⁺ spark (see also (23, 24) for additional comparison of model behavior to experimental data).